Streptolysin O: Activation by Thiols
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چکیده
منابع مشابه
Streptolysin S activation by lipoteichoic acid.
Lipoteichoic acid from streptococci and Staphylococcus aureus both activated membrane-bound precursor streptolysin S and induced the formation of extracellular streptolysin S. Lipoteichoic acid could replace other substances, such as yeast ribonucleic acid core, that act as carriers for hemolysin but which are not components of the streptococcus or the host. Lipoteichoic acid may play a role as...
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The definition of rheumatic fever has been broadened of recent years and many people take it to include not only articular and skin manifestations but also all those signs that are commonly regarded as evidence of an active carditis. While this conception may be pathologically correct and at times convenient in use, it is clear that there are many cases of rheumatic fever where there is no proo...
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When washed streptococci were incubated in a phosphate buffer containing MgSO4 and maltose (Bernheimer's basal medium) and centrifuged, no hemolytic activity was detected in the supernatant. Although incubation of the spent medium with carrier oligonucleotide did not yield active hemolysin, the mixture turned to be significantly hemolytic, upon ethanol precipitation and dehydration. Oxygen stab...
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Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome, leading to IL-1β secretion and pyroptosis. The structural determinants of pore-forming toxins required for NLRP3 activation remain unknown. Here, ...
متن کاملSynergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells.
Stimulation of phospholipase D (PLD) by cell surface receptors has been observed in many cell types. We have investigated the mechanism of activation of this enzyme in undifferentiated HL60 cells. GTP analogues and Ca2+ (buffered in the nanomolar to micromolar range) were introduced into HL60 cells in the presence of the permeabilizing agent, streptolysin O. We report that guanosine 5'-[gamma-t...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1970
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.1.5.509-510.1970